Antiviral effects of blackberry extract against herpes simplex virus type 1.

(Extraído de PubMed.gov)

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):e31-5.

Danaher RJ, Wang C, Dai J, Mumper RJ, Miller CS.

Source

Department of Oral Health Practice, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.

Abstract

OBJECTIVE:

The aim of this study was to evaluate antiviral properties of blackberry extract against herpes simplex virus type 1 (HSV-1) in vitro.

STUDY DESIGN:

HSV-infected oral epithelial (OKF6) cells and cell-free virus suspensions were treated with blackberry extract (2.24-1,400 μg/mL), and virus yield and infectivity were quantified by direct plaque assay.

RESULTS:

Blackberry extract ≥56 μg/mL inhibited HSV-1 replication in oral epithelial cells by >99% (P < .005). Concentrations ≥280 μg/mL were antiviral when the extract was added after virus adsorption and entry. Exposure of cell-free virus to ≥280 μg/mL blackberry extract for 15 minutes at room temperature was virucidal (P = .0002). The virucidal effects were not due to pH changes at concentrations up to 1,500 μg/mL.

CONCLUSIONS:

Blackberry extract inhibited the early stages of HSV-1 replication and had potent virucidal activity. These properties suggest that this natural fruit extract could provide advantage as a topical prophylactic/therapeutic agent for HSV infections.

Copyright © 2011 Mosby, Inc. All rights reserved.

PMID:

21827957

[PubMed - indexed for MEDLINE]

PMCID: PMC3154751

[Available on 2012/9/1]