AVISO IMPORTANTE


A partir del día 14 de junio de 2015, domingo, este blog dejará de ser actualizado como se ha venido haciendo hasta la fecha. La primera idea fue la de cerrar el blog, pero el deseo que que cuanto aquí se ha publicado pueda seguir siendo útil en el futuro, nos hace que mantengamos abierto el blog. Si tuviera alguna duda o quisiera hacer algún comentario, no tema hacerlo: seguiremos publicando cuantos comentarios se hagan y seguiremos contestando a las dudas que puedan surgir.
Gracias y hasta siempre.
Andrés Guerrero Serrano
-Homeópata-

martes, 23 de octubre de 2012

Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients.

(Extraído de PubMed.gov)

Support Care Cancer. 2012 Jul;20(7):1479-89. doi: 10.1007/s00520-011-1236-3. Epub 2011 Aug 5.

Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, Hickok JT, Morrow GR.

Source

Departments of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 697, Rochester, NY 14642, USA. julie_ryan@urmc.rochester.edu

Abstract
PURPOSE:

Despite the widespread use of antiemetics, nausea continues to be reported by over 70% of patients receiving chemotherapy.

METHODS:

In this double blind, multicenter trial, we randomly assigned 744 cancer patients to four arms: 1) placebo, 2) 0.5 g ginger, 3) 1.0 g ginger, or 4) 1.5 g ginger. Nausea occurrence and severity were assessed at a baseline cycle and the two following cycles during which patients were taking their assigned study medication. All patients received a 5-HT(3) receptor antagonist antiemetic on Day 1 of all cycles. Patients took three capsules of ginger (250 mg) or placebo twice daily for 6 days starting 3 days before the first day of chemotherapy. Patients reported the severity of nausea on a 7-point rating scale ("1" = "Not at all Nauseated" and "7" = "Extremely Nauseated") for Days 1-4 of each cycle. The primary outcomes were to determine the dose and efficacy of ginger at reducing the severity of chemotherapy-induced nausea on Day 1 of chemotherapy.

RESULTS:

A total of 576 patients were included in final analysis (91% female, mean age = 53). Mixed model analyses demonstrated that all doses of ginger significantly reduced acute nausea severity compared to placebo on Day 1 of chemotherapy (p = 0.003). The largest reduction in nausea intensity occurred with 0.5 g and 1.0 g of ginger (p = 0.017 and p = 0.036, respectively). Anticipatory nausea was a key factor in acute chemotherapy-induced nausea (p < 0.0001).

CONCLUSIONS:

Ginger supplementation at a daily dose of 0.5 g-1.0 g significantly aids in reduction of the severity of acute chemotherapy-induced nausea in adult cancer patients.

No hay comentarios:

Publicar un comentario en la entrada